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P. 260

Simulation and Modelling



                      Notes         In Figure 13.8, Plots of overall malaria  prevalence in a human population, with parameter
                                    values D  = 10 and D  = 20, and initial conditions N  = 500, N  = 5000 and V  = 2500.
                                           V         H                        H       V          B



                                       Did u know?  Did you know the range of values of the remaining temporal parameters of
                                       a plausible mean value?

                                       50% to 150%
                                    Comparisons with Differential-equation Models


                                    Figure  13.9 illustrates  the dynamics  of classic  differential-equation  and  differential-delay-
                                    equation “compartment” models analogous to the discrete-event model; the models we have
                                    constructed are described in detail in the Appendix, as is Macdonald’s model. Parameter values
                                    for Figure were calculated such that the prevalence curves are as closely comparable as possible
                                    to those shown in the Figure.

                                                                      Figure  13.9
                                          (A)




















                                          (B)




















                                    In Figure 13.9, an example of the time course of the overall malaria prevalence (solid lines) and
                                    the prevalence of infectious stages (dashed lines) in a human population, in (A) classic differential-
                                    equation and (B) differential-delay-equation “compartment”.





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